Monday Night Football brings us a fascinating matchup as the Carolina Panthers roll into San Francisco as 7-point road underdogs against a 49ers offense that’s finally healthy and firing again.
My Panthers vs. 49ers predictions focus on the Carolina pass-game and what is a rather low number for his No. 2 receiver.
AdvertisementAdvertisementAdvertisementRead on for my NFL picks for Monday, November 24.
Panthers vs 49ers prediction
Panthers vs 49ers Best bet: Xavier Legette Over 24.5 receiving yards (-115)
Tetairoa McMillan should stay busy on Monday night, but after Bryce Young’s historic performance last week, it’s his No. 2 option, Xavier Legette, who profiles as the best matchup play against a soft San Francisco 49ers defense.
Legette saw the second-most targets on the team last week with eight and turned them into four catches for 83 yards and a touchdown. It was his second game with 80 or more yards since Week 7, and his usage continues to trend upward.
AdvertisementAdvertisementAdvertisementThe matchup is even more favorable this week. San Francisco’s defense is already missing key contributors and may be without two additional starting linebackers. Jacoby Brissett just set the single-game completion record against this unit, and the 49ers have allowed 114 points across their last four games. This could easily be a softer matchup than Atlanta.
THE BLITZ projects Legette for 37 yards, ahead of Jalen Coker, who’s competing for WR2 targets. Legette did suffer a hip injury last week, but he was a full participant late in the week, suggesting that another strong role with 8+ target potential — especially if Carolina is chasing — is secure.
With both offenses likely moving the ball in a 50-point total, sticking with secondary receiver overs remains a profitable angle, and Legette fits that profile perfectly.
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AdvertisementAdvertisementAdvertisementPanthers vs 49ers MNF same-game parlay
It's a game with a 49.5-point total, and both of these teams were in shootouts last week where wide receivers went off. The only member that isn't included in this foursome that might have more passing yards is George Kittle, but this is a WR1+WR2 stack that is asking for Under 100 receiving yards combined for each team.
Panthers vs 49ers SGP
Xavier Legette Over 24.5 receiving yards
Ricky Pearsall Over 41.5 receiving yards
Jauan Jennings Over 47.5 receiving yards
Tetairoa McMillan Over 61.5 receiving yards
Our big-ticket SGP: TD Trio
George Kittle and Tetairoa McMillan are the two shortest non-RB TDs, and Legette was a legit target last week and caught a tuddy himself. Just remember, Brissett threw for almost 500 yards vs. the 49ers' defense last week and Brock Purdy and this offense still won 41-22.
AdvertisementAdvertisementAdvertisementPanthers vs 49ers SGP
Xavier Legette anytime touchdown
Tetairoa McMillan anytime touchdown
George Kittle anytime touchdown
Covers MNF BTEPanthers vs 49ers odds
Spread: Panthers +7 | 49ers -7
Moneyline: Panthers +290 | 49ers -370
Over/Under: Over 49.5 | Under 49.5
Panthers vs 49ers betting trend to know
The Panthers are 9-2 ATS historically in San Francisco. Find more NFL betting trends for Panthers vs. 49ers.
How to watch Panthers vs 49ers
Location
Levi's Stadium, Santa Clara, CA
Date
Monday, November 24, 2025
Kickoff
8:15 p.m. ET
TV
ESPN
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