Zachary Neel, Ducks WireSat, November 22, 2025 at 5:05 PM UTC·1 min readWith just two weeks left in the regular season, the Oregon Ducks are in a virtual postseason before the playoffs begin, needing a pair of wins to get into the College Football Playoff, in all likelihood. This weekend against the No. 15 USC Trojans, Dan Lanning will face one of his toughest tests of the season and have one of the biggest regular-season games of his career.
It makes sense that ESPN's "College GameDay" is coming to town once again for this matchup, bringing along Oregon legend Marcus Mariota as the guest picker, as well.
AdvertisementAdvertisementAdvertisementIt will be a major test for both teams, and one that could set either Dan Lanning or Lincoln Riley's squads up in a prime position to make the College Football Playoff, while a loss could be detrimental to their chances.
Here's a look at how all of the members of the show picked the game to play out:
Desmond Howard: Oregon
Pat McAfee: Oregon
Nick Saban: Oregon
Guest Picker Marcus Mariota: Oregon
Kirk Herbstreit: Oregon
The game between Oregon and USC kicks off at 12:30 p.m. PT on CBS in Eugene, OR.
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This article originally appeared on Ducks Wire: ESPN 'College GameDay' crew picks Oregon Ducks vs. USC
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