Technology

Updated Week 12 Defense Fantasy Rankings: D/ST lineup tips on who to start, best sleepers, streamers

2025-11-21 20:00
344 views
Updated Week 12 Defense Fantasy Rankings: D/ST lineup tips on who to start, best sleepers, streamers

Set your lineup with the right defense for fantasy football. Click here for The Sporting News' Week 12 D/ST rankings.

Updated Week 12 Defense Fantasy Rankings: D/ST lineup tips on who to start, best sleepers, streamersStory byVideo Player CoverGriffin MissantFri, November 21, 2025 at 8:00 PM UTC·2 min read

Updated Week 12 Defense Fantasy Rankings: D/ST lineup tips on who to start, best sleepers, streamers originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.

The D/ST position in fantasy football is often overlooked. However, selecting the right defense can be the critical factor that determines victory or defeat each week.

AdvertisementAdvertisementAdvertisement

Never start an elite NFL defense in a poor matchup, as it may not always produce fantasy points for the D/ST position. The best approach is to focus entirely on matchups.

Here are our Week 12 D/ST fantasy rankings, best starts, sleepers, and some matchups to avoid.

➕ UPGRADE YOUR TOOLS: Sign up for Yahoo Fantasy Plus

Fantasy Football Defense Rankings Week 12: Who to start, sit at D/ST

📋 Week 12 Fantasy Rankings: QB | RB | WR | TE | D/ST | PK | ​​Flex Half-PPR Cheat Sheet

Updated 11/21:

Rk

Team Defense

OPP

Rk Chg

1

Seattle Seahawks

@TEN

2

Baltimore Ravens

NYJ

⬆️ 1

3

Detroit Lions

NYG

4

Green Bay Packers

MIN

5

Cleveland Browns

@LV

6

New England Patriots

@CIN

⬆️ 1

7

Chicago Bears

PIT

8

San Francisco 49ers

CAR

9

Carolina Panthers

@SF

10

Houston Texans

BUF

TNF

11

Buffalo Bills

@HOU

TNF

12

Los Angeles Rams

TB

13

Atlanta Falcons

@NO

14

Tampa Bay Buccaneers

@LAR

⬇️ 1

15

Arizona Cardinals

JAX

16

Kansas City Chiefs

IND

⬆️ 1

17

Minnesota Vikings

@GB

18

New Orleans Saints

ATL

19

Pittsburgh Steelers

@CHI

20

Jacksonville Jaguars

@ARI

21

Las Vegas Raiders

CLE

⬆️ 1

22

Tennessee Titans

SEA

23

Philadelphia Eagles

@DAL

24

Indianapolis Colts

@KC

25

New York Giants

@DET

26

Cincinnati Bengals

NE

27

New York Jets

@BAL

28

Dallas Cowboys

PHI

BYE

Denver Broncos

BYE

BYE

Los Angeles Chargers

BYE

BYE

Miami Dolphins

BYE

BYE

Washington Commanders

BYE

Which D/STs have a bye in fantasy Week 12?

  • Denver Broncos

  • Los Angeles Chargers

  • Miami Dolphins

  • Washington Commanders

BEST PICKUPS: Week 12 waiver wire

Who are the best fantasy defenses in Week 12?

This week is full of targetable matchups at the D/ST position. You truly could not go wrong with any of the units in the top five of these rankings.

AdvertisementAdvertisementAdvertisement

Seattle has been outstanding for fantasy football this season, and it's the best possible matchup with the Tennessee Titans—the Titans average just 14.4 points per game, the lowest in the NFL.

Who are the best fantasy D/ST sleepers in Week 12?

The matchup between the Falcons and Saints is fascinating. Neither defense is that great, but the offenses are inconsistent at best.

If this is a low-scoring game, both units could find opportunities for fantasy points.

FANTASY TOOLS: NFL Player Stats | NFL Transactions | NFL Depth Charts | Fantasy Injury Reports

AdvertisementAdvertisement