Mike Masala, Niners WireWed, November 26, 2025 at 8:28 PM UTC·1 min readThe San Francisco 49ers have had some horrendous injury luck this year, especially along the defensive line, and things aren't getting any better.
With Nick Bosa, Mykel Williams and Yetur Gross-Matos on injured reserve, and Robert Beal Jr. still in concussion protocol, the 49ers lost defensive end Sam Okuayinonu on Monday night against the Carolina Panthers.
AdvertisementAdvertisementAdvertisementOn Wednesday, 49ers head coach Kyle Shanahan announced that Okuayinonu has a high ankle sprain and will miss some time.
The 27-year-old was on his way to the best year of his career, as he had 31 tackles, four quarterback hits, two sacks and one forced fumble through the first 12 games of the season.
While Beal will return to action this week, he'll join a thin group of defensive ends that includes Bryce Huff, Clelin Ferrell and Keion White. It will be interesting to see if the 49ers opt to add another edge rusher or call up one from their practice squad for Sunday's Week 13 battle with the Cleveland Browns.
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This article originally appeared on Niners Wire: Kyle Shanahan provides unfortunate injury update on Sam Okuayinonu
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