Jess Root, Cardinals WireFri, November 21, 2025 at 1:10 PM UTC·1 min readThe Arizona Cardinals, for second consecutive week, suffered a blowout loss to an NFC West rival, allowing more than 40 points. They lost 41-22 on Sunday at State Farm Stadium to the San Francisco 49ers.
49ers quarterback Brock Purdy threw three touchdown passes in his first game since Week 4, and running back Christian McCaffrey had 121 total yards of offense and scored three times.
AdvertisementAdvertisementAdvertisementThe Cardinals had big games from quarterback Jacoby Brissett, receiver Michael Wilson and tight end Trey McBride. Brissett had 452 passing yards and two touchdown passes. He set an NFL record with 47 pass completions, but he also threw two interceptions, his second consecutive game with two turnovers. Wilson had 15 receptions for 185 yards and McBride caught 10 passes for 115 yards.
So there was a lot for me and cohost Seth Cox to discuss in the latest episode of the podcast.
In this show, we discuss:
(1:00) Our reactions to the loss overall
(13:54) Michael Wilson's monster game
(20:13) The play of Jacoby Brissett
(27:21) The problems with the defense
Enjoy the show!
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This article originally appeared on Cards Wire: 49ers-Cardinals Week 11 reaction show
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