The Champions League has provided a welcome escape from this season's domestic despairs for Liverpool, and after six defeats in seven league outings, Arne Slot could certainly do with a win on Wednesday to ease the mounting pressure.
The Reds have beaten both of the Madrid clubs in their past two European fixtures at Anfield, and they have won 13 group stage/league phase games in a row on home soil - a record for an English club.
AdvertisementAdvertisementAdvertisementLiverpool's desperate need for a positive result could also see them reach two significant scoring milestones in this game - their next goal will be their 500th in the European Cup/Champions League, while Mohamed Salah needs two goals to become the first African player to score 50 in this competition.
Did you know?
PSV have won only one of their past 14 away games against English teams (D5, L8) and are without a victory in seven (D3, L4), since a 1-0 success at Tottenham in the Uefa Cup last 16, first leg in March 2008.
PSV's next goal will be their 150th in the Champions League, and they have scored in 16 of their past 17 group games.
The Dutch giants will be no pushover, and they have lost only three of their past 17 Champions League group stage/league phase matches (W7, D7), drawing both of their away games 1-1 this term.
Key PSV players - Guus Til and Ismael Saibari
The in-form Til has scored five goals in his past four games, including a hat-trick in a comprehensive 5-1 win at AZ Alkmaar a few weeks ago. The attacking midfielder spent the 2021-22 season on loan at Slot's Feyenoord. He was the club's top league scorer with 15 goals, and he helped them reach the Conference League final, where they lost 1-0 to Jose Mourinho's Roma.
AdvertisementAdvertisementAdvertisementMeanwhile, Saibari found the net in the 6-2 win over Napoli last month and followed that with a hat-trick in a 3-2 away win over Feyenoord. The Morocco international scored in the previous meeting between the clubs, which PSV won 3-2.
PSV squad summary
Croatia's Ivan Perisic is the most recognisable name from a Premier League point of view, while keep an eye on Ruben van Bommel – the son of former Bayern Munich and Barcelona midfielder Marco.