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NFL Picks Against the Spread for Every Week 13 Game

2025-11-25 19:22
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NFL Picks Against the Spread for Every Week 13 Game

Chris Vasile breaks down his favorite NFL picks against the spread for Week 13, including the Kansas City Chiefs and Buffalo Bills.

NFL Picks Against the Spread for Every Week 13 GameStory byChris VasileTue, November 25, 2025 at 7:22 PM UTC·4 min read

Week 13 is here, and it’s one of the best weeks of the entire NFL calendar.

We kick things off with a Thanksgiving triple-header on Thursday, followed by a must-see Black Friday showdown, a stacked Sunday slate, and a juicy Monday nighter.

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I’m breaking down the best Week 13 NFL picks against the spread, so let’s jump right in.

Week 13 NFL picks against the spread

Matchup

Pick

Packers vs Lions

-2.5)

Chiefs

vs

Cowboys

-3)

Bengals vs

Ravens

 

+7)

Bears vs

Eagles

+7)

Jaguars vs

Titans

+6.5)

Falcons vs

Jets

+2.5)

Rams vs

Panthers

-10.5)

Saints vs

Dolphins

+5.5)

Cardinals vs

Buccaneers

-3)

49ers vs

Browns

-5.5)

Texans vs

Colts

+4.5)

Vikings vs

Seahawks

-10.5)

Bills vs

Steelers

-3.5)

Raiders vs

Chargers

-9.5)

Broncos vs

Commanders

-6.5)

Giants vs

Patriots

-7.5)

Lines courtesy of FanDuel.

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Expert Week 13 NFL ATS picks

Packers vs. Lions: Lions (-2.5)

The Detroit Lions were caught in a lookahead spot last week, which is why they needed overtime vs. the Giants. On a short week, with no travel, the Lions offense should be able to outscore the Packers' inconsistent offense.

Chiefs vs. Cowboys: Chiefs (-3)

The Chiefs also needed OT to fend off the Colts, but now they get a favorable matchup against a piss-poor defense. I expect Mahomes to carve up the Dallas secondary with ease.

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Bengals vs. Ravens: Bengals (+7)

Joe Burrow will be back under center for the Bengals here, and that's enough to entice me to grab the +7 points in this divisional game. The Ravens were held to just 241 yards last week vs. the Jets, so covering more than a TD doesn't sound too appealing.

Bears vs. Eagles: Bears (+7)

Speaking of appealing, the Bears look like a legit threat in the NFC while the Eagles appear to be going through the motions once again. Consistency is key, just like when making gravy. Take the Bears.

Jaguars vs. Titans: Titans (+6.5)

The Titans are that one team I refuse to pick against. Whether it be stupidity or other reasons that I cannot control, I don't think they should be as bad as they are. Too. Many. Points.

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Falcons vs. Jets: Jets (+2.5)

Speaking of birds, the Atlanta Falcons are what you think a turkey should be, before you actually taste it. Disappointing. Injuries have played a huge part in their down season, but a win vs. the Saints doesn't make them good. I'm calling the Jets to win this outright.

Rams vs. Panthers: Rams (-10.5)

Is he good, or is he bad? That's the weekly question surrounding Bryce Young. You know who is good, tho? Matthew Stafford. He'll continue to have this Rams offense humming in a runaway victory.

Saints vs. Dolphins: Saints (+5.5)

When you have bad vs. worse, you always have to take the points, which is what I'll do here with the Saints.

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Cardinals vs. Buccaneers: Buccaneers (-3)

I don't think the Buccaneers are as bad as they looked last week. Baker Mayfield should be back, and I trust him more than Jacoby Brissett.

49ers vs. Browns: 49ers (-5.5)

Shedeur Sanders got his first win as an NFL starter last week, and this week, he'll suffer his first loss. If Brock Purdy can protect the ball, this game shouldn't be close.

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Texans vs. Colts: Texans (+4.5)

Maybe I underestimated the Texans' defense, which was nails last week against the Bills. I say they give Daniel Jones fits here while slowing down Jonathan Taylor. Grab the points in this divisional clash.

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Vikings vs. Seahawks: Seahawks (-10.5)

I'm out on the Vikings as a team, and with good reason. J.J. McCarthy will likely miss this game with a concussion, which means Max Brosmer will be tossed into the fire. Take the Seahawks on the Alt line of -16.5 at +178.

Bills vs. Steelers: Bills (-3.5)

Whether it's Aaron Rodgers or Mason Rudolph, I don't like the Steelers' chances. The Bills' offensive line was bullied to a man last week, but I think they'll be much better in this spot. Take the better offense.

Raiders vs. Chargers:  Chargers (-9.5)

I will not back the Raiders the rest of the year. This is my promise to you.

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Broncos vs. Commanders: Broncos (-6.5)

Both teams are coming off a bye, but one is playing for a division title, while the other is playing out the string. If the Broncos are anything less than 100% focused on this one, I would be shocked.

Giants vs. Patriots:  Patriots (-7.5)

In Drake Maye we trust.

My NFL ATS record is 87-90-1 this season for -9 units.

Odds are correct at the time of publishing and are subject to change.Not intended for use in MA.Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

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